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National Psoriasis Foundation

Psoriasis Research and Resources

A review of Phototherapy protocols for psoriasis treatment

Lapolla W, Yentzer BA, Bagel J, Halvorson CR, Feldman SR. Journal of the American Academy of Dermatology Volume 64, Issue 5 , Pages 936-949, May 2011

Summary. Phototherapy is a mainstay in the treatment of psoriasis. Phototherapy can be administered in the hospital, outpatient clinic, or in the patient's home. The purpose of this review is to provide some practical guidance to dermatologists on the specifics of using Phototherapy which remains one of our most safe and effective treatment strategies for psoriasis care. We conducted a literature review of home Phototherapy, BB-UVB, NB-UVB, and PUVA Phototherapy. NB-UVB is more effective than BB-UVB and safer than PUVA. Typical regimens for NB-UVB involve dosing 3 times per week for at least 3 months. Treatment must be independently developed to suit each participant's needs. Ultraviolet light is an effective, relatively safe modality that is a valuable tool in the treatment of psoriasis. NB-UVB Phototherapy is considered the first-line treatment for extensive plaque type psoriasis.

Quality of life in psoriasis improves after standardized administration of narrowband UVB Phototherapy

Lim C. The Australasian Journal Of Dermatology, 2006 Feb; Vol. 47 (1), pp. 37-40; PMID: 16405481

Summary: Psoriasis is a chronic fluctuating dermatosis with demonstrable impact on patients' quality of life. Our aim was to investigate if narrowband UVB Phototherapy administered to psoriasis patients in a standardized manner leads to an improvement in patients' perceived quality of life. Patients with psoriasis were recruited from referrals to the Skin and Cancer Foundation, Australia between January 1998 and September 2002. Patients had psoriasis inadequately controlled by topical therapies alone and no contraindications to the use of Phototherapy treatment. Patients completed a pre- and post-therapy questionnaire on quality of life parameters. The differences in mean and standard deviation of quality of life parameters were measured using a paired sample t-test based on pre- and post-phototherapy questionnaires. 90 psoriasis patients were included in the study. The course of narrowband UVB Phototherapy was found to significantly improve quality of life in psoriasis patients (P <or= 0.005).

Cost-effectiveness of moderate-to-severe psoriasis treatment

Miller DW. Expert Opinion On Pharmacotherapy, 2006 Feb; Vol. 7 (2), pp. 157-67; PMID: 16433581

Psoriasis is a common, chronic inflammatory disease that can cause as much disability as cancer, diabetes or other major medical illnesses. Traditional therapy for treating moderate-to-severe psoriasis include Phototherapy, methotrexate, oral retinoids and ciclosporin. New biological treatment provide further therapeutic options, but add to the already considerable cost of managing psoriasis. When considering cost-effectiveness in addition to safety and efficacy, ultraviolet Type B (UVB) Phototherapy lights seem to be the best first-line treatment for the control of moderate-to-severe psoriasis. The biologics should be considered as second-line agents alongside the traditional systemic treatments when Phototherapy proves to be ineffective or is otherwise contraindicated, such as in patients with psoriatic arthritis.



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